Distortion correction of MR data in whole-body small animal PET-MR using 3D thin-plate splines

European Institute for Molecular Imaging (EIMI) – University of Muenster, Germany MR imaging suffers from geometric distortion caused by gradient nonlinearities at the edges of the gradients in large Field-of-Views (FOV). Therefore, the fusion of PET and MR data can be deficient. This can be an important aspect in whole-body imaging as well as for volumetric measurements. In this work a marker-based method is presented to increase the accuracy of the fusion of PET and MR data by correcting for these geometric distortions through 3D thin-plate splines [1]. For the determination of the geometric distortion in the MR data a customized phantom (112 mm in length) with a 3-dimensional grid of 575 (5x5x23) sphere-shaped fillable control points has been developed. Phantom MR data is acquired with two standard MR sequences (FLASH, RARE) on a BioSpec 94/20 (Bruker). Additionally, a 20 minute [F18]-FDG PET scan of the phantom is performed on a quadHIDAC-PETscanner (Oxford Positron Systems). The positions of the control points are determined semiautomatically on both MR (distorted grid) and PET data (reference grid). The transformation between both modalities is calculated with 3D thin-plate splines (3D TPS). The calculated transformation is then applied to whole-body mouse data, which is acquired with the same scan parameters as used in the phantom scans.